Established in 1929, Athlone Hospital in Lobatse was the first goverment hospital in Botswana during the colonial era. Before its inception, only mission hospitals such as Scottish Livingstone in Molepolole and Seventh Day Adventist in Kanye were operational.

Officillay opened on August 2008, Mahalapye District Hospital is one of the four district hospitals that have recently completed as part of government efforts to improve people's access to medical care as well as introduce specialist services closer to the community.

Sekgoma Memorial Hopsital (SMH) is atate of the art hospital situatted in the outskirts of the Bangwato capital, Serowe along the Serowe-Palapye road in the Central district. SMH which offers high quality health care was officially opened in 1928. The hospital is named after Kgosi Sekgoma I, who was the Paramount Chief of Bamangwato in the 1920's.

The Selebi Phikwe Government Hospital which started as a clinic in 1970 is situated in the Central District of Botswana, approximately 150 kilometers south east of the city of Francistown. The hospital which opened its doors with a bed capicity of 65, now caters for projected 44 661 people. When the hospital started around 1970 it catered mainly for residents of selebi Phikwe which was a mushroom mine area. At that time a dwelling house was used as clinic

Letsholathe II Memorial Hospital opened its doors to the public on September 25, 2008 under the leadership of the Chief Medical Officer, Richard Kambinda. The state of the art facility is situated 10 kilometers northwest of Maun village along the Maun-Shorobe road.